19-05-2020, 01:09 AM
Saiu uma pesquisa que mostra um risco maior de forma grave da doença para os pacientes que fizeram uso de Ibuprofeno.
https://www.researchsquare.com/article/r...iknyVqMlLY
Results: Among 1,872 patients, 46 (2.5%) were exposed to ibuprofen prior to COVID-19 infection. Patients with recent ibuprofen exposure tended to be older and more likely to have hypertension, diabetes, myocardial infarction, chronic obstructive pulmonary disease, and cancer, though all insignificant (P>0.05). When adjusting for these covariates, odds ratio was 1.57 [95% CI 0.72-3.38], with 12 ibuprofen-exposed patients meeting the endpoint (26.1% [95% CI 13.4-38.8%]) versus 272 unexposed patients (14.9% [95% CI 13.4-16.4%]), P=0.15.
Conclusion: The association between ibuprofen and severe COVID-19 was insignificant, although with a trend towards increased disease severity risk.
Outros dados mostraram que falta de vitamina K pode ser um fator de risco agravante:
Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
https://www.preprints.org/manuscript/202004.0457/v1
Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19
E após algumas meta-análises sobre a baixa prevalência de fumantes internados, na França a nicotina está sendo testada como protetor contra contaminação nas equipes, e como inibidora da tempestade de citocinas nos pacientes. Os Ingleses estão para começar seus próprios testes.
Por que fumantes estão sendo menos hospitalizados por coronavírus?
https://www.vice.com/pt_br/article/epgyj...oronavirus
French researchers suggest nicotine could protect against coronavirus
http://www.rfi.fr/en/science-and-technol...t-covid-19
AN NHS hospital is set to trial nicotine patches as a treatment for coronavirus.
Studies of hospitalised Covid-19 patients across the globe have shown a surprisingly low prevalence of smokers.
https://www.thesun.co.uk/news/11651302/n...treatment/
Por fora, a fabricante do Lucky Strike desenvolveu uma vacina, provavelmente baseada em nicotina:
British American Tobacco says potential coronavirus vaccine using tobacco leaves ready for human trialS
https://www.deccanherald.com/science-and...38659.html
Este estudo associou a glicose em jejum dos pacientes no momento da internação com o agravamento dos casos e morte. Acima de 126 mg/dL (valor convertido) foi praticamente uma sentença de morte, comprovando que os diabéticos correm maior risco:
Correlation between Fasting Blood Glucose Level at Admission and Mortality in COVID-19 Patients: A Retrospective Study
https://www.researchsquare.com/article/rs-18484/v1
Este estudo computacional avaliou que as catequinas (chá-verde) e curcuminas (açafrão) possuem alta energia de ligação com a proteína ACE2 e com as proteínas S1 do vírus, ou seja, sua presença no organismo poderia diminuir a disponibilidade de receptores ACE2, ao mesmo tempo que poderia inabilitar as proteínas da capa do vírus para a entrada nas células:
Catechin and Curcumin interact with corona (2019-nCoV/SARS-CoV2) viral S protein and ACE2 of human cell membrane
https://www.researchsquare.com/article/rs-22057/v1
https://www.researchsquare.com/article/r...iknyVqMlLY
Results: Among 1,872 patients, 46 (2.5%) were exposed to ibuprofen prior to COVID-19 infection. Patients with recent ibuprofen exposure tended to be older and more likely to have hypertension, diabetes, myocardial infarction, chronic obstructive pulmonary disease, and cancer, though all insignificant (P>0.05). When adjusting for these covariates, odds ratio was 1.57 [95% CI 0.72-3.38], with 12 ibuprofen-exposed patients meeting the endpoint (26.1% [95% CI 13.4-38.8%]) versus 272 unexposed patients (14.9% [95% CI 13.4-16.4%]), P=0.15.
Conclusion: The association between ibuprofen and severe COVID-19 was insignificant, although with a trend towards increased disease severity risk.
Outros dados mostraram que falta de vitamina K pode ser um fator de risco agravante:
Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
https://www.preprints.org/manuscript/202004.0457/v1
Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19
E após algumas meta-análises sobre a baixa prevalência de fumantes internados, na França a nicotina está sendo testada como protetor contra contaminação nas equipes, e como inibidora da tempestade de citocinas nos pacientes. Os Ingleses estão para começar seus próprios testes.
Por que fumantes estão sendo menos hospitalizados por coronavírus?
https://www.vice.com/pt_br/article/epgyj...oronavirus
French researchers suggest nicotine could protect against coronavirus
http://www.rfi.fr/en/science-and-technol...t-covid-19
AN NHS hospital is set to trial nicotine patches as a treatment for coronavirus.
Studies of hospitalised Covid-19 patients across the globe have shown a surprisingly low prevalence of smokers.
https://www.thesun.co.uk/news/11651302/n...treatment/
Por fora, a fabricante do Lucky Strike desenvolveu uma vacina, provavelmente baseada em nicotina:
British American Tobacco says potential coronavirus vaccine using tobacco leaves ready for human trialS
https://www.deccanherald.com/science-and...38659.html
Este estudo associou a glicose em jejum dos pacientes no momento da internação com o agravamento dos casos e morte. Acima de 126 mg/dL (valor convertido) foi praticamente uma sentença de morte, comprovando que os diabéticos correm maior risco:
Correlation between Fasting Blood Glucose Level at Admission and Mortality in COVID-19 Patients: A Retrospective Study
https://www.researchsquare.com/article/rs-18484/v1
Este estudo computacional avaliou que as catequinas (chá-verde) e curcuminas (açafrão) possuem alta energia de ligação com a proteína ACE2 e com as proteínas S1 do vírus, ou seja, sua presença no organismo poderia diminuir a disponibilidade de receptores ACE2, ao mesmo tempo que poderia inabilitar as proteínas da capa do vírus para a entrada nas células:
Catechin and Curcumin interact with corona (2019-nCoV/SARS-CoV2) viral S protein and ACE2 of human cell membrane
https://www.researchsquare.com/article/rs-22057/v1
